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He is author of 5 books and over 400 scientific articles on ophthalmology. His main research and innovations have been in the field of dacryology: for dry-eye conditions he introduced the diagnosis of lacunar sulci retraction, the occlusion of the canaliculi by patching the lacrimal puncta with autologous skin and conjunctiva, the salivary gland transplantation to the eye, the subcutaneous abdominal pump-reservoirs for severe dry-eye. His Triple Classification of Dry Eye has became the most used worldwide. For watery-eye conditions he introduced the carunculo-canalicular vent to diagnose and treat canalicular occlusions, the bicanalicular ring intubation, the dacryo-fornyx-rhinostomy, the contralateral nasal occlusion to avoid the inflammation of dacryo-cysto-rhinostomies, and the Z-plasty and YV-plasty for conjunctivochalasis. In tear physiology he showed the tearing function of REM sleep, and the trans-tarsal influence of tears on the meibomian gland secretion. In other fields of ophthalmology, he performed the first surgical restrictions of the paralytic pupil (coremeiosis), the suture of iridodialysis through a single piercing of the cornea, the juxtaciliar excision of the chalazia, the intraocular penetration of retrobulbar drugs after ocular compression, etc.
As a philologist, he has published articles about the influence of English in the different medical literatures, the origin of the names of the colors, the end of the tower of Babel, etc. and he has introduced many neologisms in the ophthalmological lexicon, such as dacryology, xero-dacryology and odo-dacryology, lacunar sulci, conjuctival trigoni, cisterna lacrimalis, mare lacrimale, dacryodochus, tantalic dry eye, bicanalicular, amphiopia and amphimetropia, fentobiomicroscopy, etc. As a historian, he has studied the Saharian ophthalmology, the history of spectacles and its influence in the Rinascimento, and the life of several outstanding ophtalmologists such as Rizal, Schirmer, De Roetth, and his professor Castroviejo, in fact, when Castroviejo died it was Prof Murube who harvested and transplanted his corneas. In psycho-sciences, he showed that emotional tearing came as a mimic language for human interrelation, and that it has two basic forms: an appeal for help, and just the opposite, an offer of help or solidarity.
He is a member of the Academia Ophtalmologica Internationalis, and has been awarded the gold medal of the Trachoma Society, the gold medal of the Asia-Pacific Association of Ophthalmic Surgeons, the gold medal of the Saudi Ophthalmological Society, etc. He is a member emeritus of numerous universities and Ophthalmological Societies, particularly in Latin America and the Philippines. He founded the Canary Society of Ophthalmology (1971), and the International Society of Dacryology (1982), was editor of the Spanish Archives of Ophthalmology, and currently is a member of the Editorial Board of many international journals of ophthalmology. He was also President of Highlights of Ophthalmology. At present he is president of the Spanish Society of Ophthalmology.
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